P-glycoprotein and multidrug resistance.

@article{Gottesman1996PglycoproteinAM,
  title={P-glycoprotein and multidrug resistance.},
  author={Michael M. Gottesman and Ira Pastan and Suresh V Ambudkar},
  journal={Current opinion in genetics & development},
  year={1996},
  volume={6 5},
  pages={
          610-7
        }
}
Although the phenomenon of simultaneous resistance to multiple cytotoxic drugs (multidrug resistance) in cancer cells has been discussed for more than two decades, and the human and mouse genes encoding an energy-dependent transporter (the multidrug transporter or P-glycoprotein) responsible for multidrug resistance were cloned 10 years ago, there is still considerable controversy about the mechanism of action of this efflux pump and its true biological function. This review summarizes the… CONTINUE READING

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