P-glycoprotein and multidrug resistance-associated protein 2 are oppositely altered in brain of rats with thioacetamide-induced acute liver failure.

@article{Jin2013PglycoproteinAM,
  title={P-glycoprotein and multidrug resistance-associated protein 2 are oppositely altered in brain of rats with thioacetamide-induced acute liver failure.},
  author={Shi Jin and Xin-ting Wang and Li Liu and Dan dan Yao and Can Liu and Mian Zhang and Hai-fang Guo and Xiao-dong Liu},
  journal={Liver international : official journal of the International Association for the Study of the Liver},
  year={2013},
  volume={33 2},
  pages={
          274-82
        }
}
BACKGROUND P-glycoprotein (P-GP) and multidrug resistance-associated protein 2 (MRP2) are involved in transport of many drugs across blood-brain barrier (BBB). The function and expression of P-GP and MRP2 may be modulated by different pathologies. Acute liver failure (ALF) was reported to impair BBB function, resulting in the increased BBB permeability. AIMS We investigated whether ALF altered function and expression of P-GP and MRP2 in brain of thioacetamide-induced ALF rats. METHODS ALF… CONTINUE READING
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