P-glycoprotein and drug resistance in acute leukemias and in the blastic crisis of chronic myeloid leukemia.

@article{Carulli1990PglycoproteinAD,
  title={P-glycoprotein and drug resistance in acute leukemias and in the blastic crisis of chronic myeloid leukemia.},
  author={Giovanni Carulli and Mario Petrini and Ann Marini and Francesca Vaglini and Francesco Caracciolo and Bruno Grassi},
  journal={Haematologica},
  year={1990},
  volume={75 6},
  pages={516-21}
}
The aim of this work is to evaluate the relationship between P-glycoprotein expression in circulating blasts and clinical response in patients suffering from acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, and chronic myeloid leukemia in either lymphoid or myeloid blastic crisis. The results obtained show that: a) patients whose blasts express P-glycoprotein are resistant towards protocols including Doxorubicin, Daunorubicin, Etoposide, Mithramycin, Vincristine; b) P… CONTINUE READING