P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy.

  title={P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy.},
  author={Albert Breier and Miroslav Baran{\vc}{\'i}k and Zdenka Sulov{\'a} and Branislav Uhr{\'i}k},
  journal={Current cancer drug targets},
  volume={5 6},
Multidrug resistance (MDR) of neoplastic tissues is a major obstacle in cancer chemotherapy. The predominant cause of MDR is the overexpression and drug transport activity of P-glycoprotein (P-gp, a product of the MDR gene). P-gp is a member of the ATP binding cassette (ABC) transporters family, with broad substrate specificity for several substances including anticancer drugs, linear and cyclic peptides, inhibitors of HIV protease, and several other substances. The development of P-gp-mediated… CONTINUE READING


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