P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy.

@article{Breier2005PglycoproteinimplicationsOM,
  title={P-glycoprotein--implications of metabolism of neoplastic cells and cancer therapy.},
  author={Albert Breier and Miroslav Baran{\vc}{\'i}k and Zdenka Sulov{\'a} and Branislav Uhr{\'i}k},
  journal={Current cancer drug targets},
  year={2005},
  volume={5 6},
  pages={457-68}
}
Multidrug resistance (MDR) of neoplastic tissues is a major obstacle in cancer chemotherapy. The predominant cause of MDR is the overexpression and drug transport activity of P-glycoprotein (P-gp, a product of the MDR gene). P-gp is a member of the ATP binding cassette (ABC) transporters family, with broad substrate specificity for several substances including anticancer drugs, linear and cyclic peptides, inhibitors of HIV protease, and several other substances. The development of P-gp-mediated… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 174 references

Small Molecules that Dramatically Alter Multidrug Current Cancer

  • R. V. Kondratov, P. G. Komarov, Y. Becker, A. Ewenson, A. V. Gudkov
  • Drug Targets,
  • 2005
1 Excerpt

The Multidrug Resistance Phenotype: 31P Nuclear Magnetic 466 Current Cancer

  • O. Kaplan, J. W. Jaroszewski, +5 authors J. S. Cohen
  • Drug Targets,
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…