P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias.

@article{Damiani1998PglycoproteinA,
  title={P-glycoprotein (PGP), and not lung resistance-related protein (LRP), is a negative prognostic factor in secondary leukemias.},
  author={Daniela Damiani and Mariagrazia Michieli and Anna Ermacora and Anna Candoni and Donatella Raspadori and Antonella Geromin and Raffaella Stocchi and Stefania Grimaz and Paola Masolini and Angela Michelutti and Rik J. Scheper and Michele Baccarani},
  journal={Haematologica},
  year={1998},
  volume={83 4},
  pages={290-7}
}
BACKGROUND AND OBJECTIVE In cell lines, there is an ongoing debate about the role of the lung resistance-related protein (LRP) whereas the role played by P-glycoprotein (PGP) in determining a multidrug resistance is well known. The aim of this study was to evaluate the frequency and the role of a PGP and an LRP overexpression in affecting the intracellular daunorubicin accumulation (IDA) and in predicting the therapy outcome on a subset of overt secondary acute non lymphocytic leukemias (ANLL… CONTINUE READING
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