P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations.

@article{Cascorbi2011PglycoproteinTD,
  title={P-glycoprotein: tissue distribution, substrates, and functional consequences of genetic variations.},
  author={Ingolf Cascorbi},
  journal={Handbook of experimental pharmacology},
  year={2011},
  volume={201},
  pages={261-83}
}
P-glycoprotein (ABCB1, MDR1) belongs to the ABC transporter family transporting a wide range of drugs and xenobiotics from intra- to extracellular at many biological interfaces such as the intestine, liver, blood-brain barrier, and kidney. The ABCB1 gene is highly polymorphic. Starting with the observation of lower duodenal protein expression and elevated digoxin bioavailability in relation to the 3435C>T single nucleotide polymorphism, hundreds of pharmacokinetic and outcome studies have been… CONTINUE READING

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