P-glycoprotein: from genomics to mechanism

@article{Ambudkar2003PglycoproteinFG,
  title={P-glycoprotein: from genomics to mechanism},
  author={Suresh V. Ambudkar and Chava Kimchi-Sarfaty and Zuben E. Sauna and Michael M. Gottesman},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={7468-7485}
}
Resistance to chemically different natural product anti-cancer drugs (multidrug resistance, or MDR) results from decreased drug accumulation, resulting from expression of one or more ATP-dependent efflux pumps. The first of these to be identified was P-glycoprotein (P-gp), the product of the human MDR1 gene, localized to chromosome 7q21. P-gp is a member of the large ATP-binding cassette (ABC) family of proteins. Although its crystallographic 3-D structure is yet to be determined, sequence… 
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