P glycoprotein: a new mechanism to control drug-induced nephrotoxicity.

@article{Moral1998PGA,
  title={P glycoprotein: a new mechanism to control drug-induced nephrotoxicity.},
  author={Raimundo Garc{\'i}a Del Moral and Asunci{\'o}n Olmo and M Aguilar and Francisco O'Valle},
  journal={Experimental nephrology},
  year={1998},
  volume={6 2},
  pages={
          89-97
        }
}
The role of P glycoprotein (P-gp) in kidney is now being explored, and under physiological conditions, this protein is thought to be an excretory pump of cationic xenobiotics and metabolites. Functionally, two different types of P-gp have been described, but only the class I has been related to drug transport, and its overexpression confers the multidrug resistance phenotype in tumoral cells. It has been proposed that P-gp is involved in the energy-dependent transport of substrates through the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

Hyperglycemia induced down-regulation of renal P-glycoprotein expression.

  • European journal of pharmacology
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 66 REFERENCES

CF: Protein-kinase-C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein

P Gros, PA McNaughton, Higgins
  • J Biol Chem 1996;271:13668–13674
  • 1996