P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential.

@article{Alemn2003PglycoproteinEI,
  title={P-glycoprotein, expressed in multidrug resistant cells, is not responsible for alterations in membrane fluidity or membrane potential.},
  author={Claudina Alem{\'a}n and Jean-Philippe Annereau and Xing-Jie Liang and Carol O Cardarelli and Barbara Taylor and Jun Jie Yin and Adorjan Aszalos and Michael M. Gottesman},
  journal={Cancer research},
  year={2003},
  volume={63 12},
  pages={3084-91}
}
Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to MDR in tumors. However, the physiological role of P-gp in normal tissues is not well understood. Previous studies on multidrug-resistant cells have suggested changes in membrane fluidity and membrane potential associated with P-gp expression, but interpretation of these studies is difficult, because most experimental cells have been selected for long periods in the presence of cytotoxic drugs and may… CONTINUE READING

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