P-cadherin-mediated Rho GTPase regulation during collective cell migration


This commentary addresses the role of P-cadherin in collective cell migration (CCM), a cooperative and coordinated migration mode, used by cells during normal and pathological migration processes. We discuss how cadherin-mediated cell-cell junctions (CCJs) play a critical role in CCM through their ability to regulate Rho GTPase-dependent pathways and how this leads to the generation and orientation of mechanical forces. We will also highlight the key function of P-cadherin (a poor prognostic marker in several tumors) in promoting collective cell movement in epithelial and mesenchymal cells.

DOI: 10.1080/21541248.2016.1173772

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@inproceedings{Plutoni2016PcadherinmediatedRG, title={P-cadherin-mediated Rho GTPase regulation during collective cell migration}, author={C{\'e}dric Plutoni and Elsa Bazelli{\`e}res and C{\'e}cile Gauthier-Rouvi{\`e}re}, booktitle={Small GTPases}, year={2016} }