P-cadherin expression predicts clinical outcome in oral squamous cell carcinomas.

  title={P-cadherin expression predicts clinical outcome in oral squamous cell carcinomas.},
  author={Lorenzo Lo Muzio and Giuseppe Pannone and Michele Davido Mignogna and Stefania Staibano and Maria A Mariggi{\`o} and Corrado Rubini and Maurizio Procaccini and Marcello Dolci and Pantaleo Bufo and Gaetano De Rosa and Adriano Piattelli},
  journal={Histology and histopathology},
  volume={19 4},
P-cadherin, a transmembrane molecule similar to E-cadherin involved in the cell-cell adhesion, and catenins form complexes between its cytoplasmic domain and the cytoskeleton. Five cell lines, 108 specimens of oral squamous cell carcinomas (OSCC), 9 metastasis and 10 of normal oral mucosa were examined to evaluate P-cadherin expression and cellular localization by immunohistochemistry and western-blotting. In normal oral mucosa there was a membranous expression only in basal and parabasal… CONTINUE READING