P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages.

@article{Burdick2010PBP,
  title={P body-associated protein Mov10 inhibits HIV-1 replication at multiple stages.},
  author={Ryan C. Burdick and Jessica L Smith and Chawaree Chaipan and Yeshitila N Friew and Jianbo Chen and Narasimhan J. Venkatachari and Krista A Delviks-Frankenberry and Wei-Shau Hu and Vinay K Pathak},
  journal={Journal of virology},
  year={2010},
  volume={84 19},
  pages={10241-53}
}
Recent studies have shown that APOBEC3G (A3G), a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, is localized to cytoplasmic mRNA-processing bodies (P bodies). However, the functional relevance of A3G colocalization with P body marker proteins has not been established. To explore the relationship between HIV-1, A3G, and P bodies, we analyzed the effects of overexpression of P body marker proteins Mov10, DCP1a, and DCP2 on HIV-1 replication. Our results show that… CONTINUE READING
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