P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.

@article{Yamada2006PTEFbmediatedPO,
  title={P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.},
  author={Tomoko Yamada and Yuki Yamaguchi and Naoto Inukai and Sachiko Okamoto and Takashi Mura and Hiroshi Handa},
  journal={Molecular cell},
  year={2006},
  volume={21 2},
  pages={227-37}
}
Human DSIF, a heterodimer composed of hSpt4 and hSpt5, plays opposing roles in transcription elongation by RNA polymerase II (RNA Pol II). Here, we describe an evolutionarily conserved repetitive heptapeptide motif (consensus = G-S-R/Q-T-P) in the C-terminal region (CTR) of hSpt5, which, like the C-terminal domain (CTD) of RNA Pol II, is highly phosphorylated by P-TEFb. Thr-4 residues of the CTR repeats are functionally important phosphorylation sites. In vitro, Thr-4 phosphorylation is… CONTINUE READING
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