P-TEFb kinase recruitment and function at heat shock loci.

  title={P-TEFb kinase recruitment and function at heat shock loci.},
  author={John T Lis and Paul M. Mason and Jinrong Peng and David H Price and Janis Werner},
  journal={Genes & development},
  volume={14 7},
P-TEFb, a heterodimer of the kinase Cdk9 and cyclin T, was isolated as a factor that stimulates formation of productive transcription elongation complexes in vitro. Here, we show that P-TEFb is located at >200 distinct sites on Drosophila polytene chromosomes. Upon heat shock, P-TEFb, like the regulatory factor HSF, is rapidly recruited to heat shock loci, and this recruitment is blocked in an HSF mutant. Yet, HSF binding to DNA is not sufficient to recruit P-TEFb in vivo, and HSF and P-TEFb… CONTINUE READING


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