P-Ser-HPr--a link between carbon metabolism and the virulence of some pathogenic bacteria.

@article{Deutscher2005PSerHPraLB,
  title={P-Ser-HPr--a link between carbon metabolism and the virulence of some pathogenic bacteria.},
  author={Josef Deutscher and Rana Herro and Alexa Bourand and Ivan Mijakovic and Sandrine Poncet},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1754 1-2},
  pages={118-25}
}
HPr kinase/phosphorylase phosphorylates HPr, a phosphocarrier protein of the phosphoenolpyruvate:carbohydrate phosphotransferase system, at serine-46. P-Ser-HPr is the central regulator of carbon metabolism in Gram-positive bacteria, but also plays a role in virulence development of certain pathogens. In Listeria monocytogenes, several virulence genes, which depend on the transcription activator PrfA, are repressed by glucose, fructose, etc., in a catabolite repressor (CcpA)-independent… CONTINUE READING