P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

  title={P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.},
  author={Hans Rosenfeldt and Jos{\'e} V{\'a}zquez-Prado and J. Silvio Gutkind},
  journal={FEBS letters},
  volume={572 1-3},
We have identified an activator of Rac, P-REX2, that is structurally related to the exchange factor PtdIns(3,4,5)-dependent Rac exchanger (P-REX1), but exhibits distinct tissue-specific expression. P-REX2 is spliced into two RNA species, approximately 3.5 and approximately 10 kb in size. The cDNA corresponding to the smaller transcript encodes a protein that exhibits strong similarity with P-REX1 within its N-terminal domains, but differs in the C-terminal region. P-REX2 promoted increased… CONTINUE READING

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