P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.

@article{Szeto1996POTXAP,
  title={P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.},
  author={Daniel P. Szeto and Aimee K. Ryan and Shawn M. O'Connell and Michael G. Rosenfeld},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 15},
  pages={7706-10}
}
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the… CONTINUE READING
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