P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.

@article{Potschka2002PGlycoproteinmediatedEO,
  title={P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.},
  author={Heidrun Potschka and Maren Fedrowitz and Wolfgang L{\"o}scher},
  journal={Neuroscience letters},
  year={2002},
  volume={327 3},
  pages={173-6}
}
Although a series of new antiepileptic drugs (AEDs) have been launched in the last two decades, drug-refractoriness remains a major problem concerning 20-30% of epileptic patients. The fact that most patients with refractory epilepsy are resistant to several AEDs acting via different targets points to an involvement of unspecific mechanisms like changes in local uptake of AEDs in the epileptic focus region. Increased expression of multidrug transporters has been reported in epileptogenic brain… CONTINUE READING

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