P-Glycoprotein Increases from Proximal to Distal Regions of Human Small Intestine

@article{Mouly2003PGlycoproteinIF,
  title={P-Glycoprotein Increases from Proximal to Distal Regions of Human Small Intestine},
  author={St{\'e}phane Mouly and Mary Paine},
  journal={Pharmaceutical Research},
  year={2003},
  volume={20},
  pages={1595-1599}
}
Purpose. The contribution of the efflux transporter P-glycoprotein (P-gp) as a barrier to drug absorption may depend on its level of expression at the site of absorption. Accordingly, the distribution of P-gp was examined along the entire length of the human small intestine. Methods. Homogenates prepared from mucosal scrapings from every other 30-cm segment of four unrelated human donor small intestines were analyzed for P-gp and the control protein villin by Western blot. Results. In each… CONTINUE READING