P-Glycoprotein Expression in Mouse Brain Increases with Maturation

@article{Tsai2002PGlycoproteinEI,
  title={P-Glycoprotein Expression in Mouse Brain Increases with Maturation},
  author={Catherine E. Tsai and M. Daood and R. Lane and T. W. Hansen and E. Gruetzmacher and J. Watchko},
  journal={Neonatology},
  year={2002},
  volume={81},
  pages={58 - 64}
}
  • Catherine E. Tsai, M. Daood, +3 authors J. Watchko
  • Published 2002
  • Biology, Medicine
  • Neonatology
  • The mdr1a isoform of P-glycoprotein (Pgp) is an integral plasma membrane efflux pump expressed in adult brain capillary endothelial cells and astrocytes of the blood-brain barrier. We determined the developmental pattern of Pgp expression in brain tissue at embryonic day 16 (E16), day of life 0 (D0), day of life 7 (D7), day of life 21 (D21), and adults (Ad). The relative expression of Pgp mRNA and protein was indexed as a percent (mean ± SEM) of D0 levels. Pgp mRNA levels increased… CONTINUE READING
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