P-450 metabolites of arachidonic acid in the control of cardiovascular function.

@article{Roman2002P450MO,
  title={P-450 metabolites of arachidonic acid in the control of cardiovascular function.},
  author={Richard J Roman},
  journal={Physiological reviews},
  year={2002},
  volume={82 1},
  pages={
          131-85
        }
}
  • R. Roman
  • Published 2002
  • Biology, Medicine
  • Physiological reviews
Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. EETs are endothelium-derived vasodilators that hyperpolarize vascular smooth muscle (VSM) cells by activating K(+) channels. 20… 

Role of 20-hydroxyeicosatetraenoic vascular system acid ( 20-HETE ) in

Recent findings implicating a critical role for 20-HETE in altering cardiovascular function in a variety of pathological conditions are summarized.

Regulation of renal microvascular 20-hydroxyeicosatetraenoic acid (20-HETE) levels.

The kidney possesses a large capacity to generate cytochrome P450 (CYP) dependent arachidonic acid (AA) metabolites, chiefly the ω and ω -1 hydroxylase-derived metabolites, and lesser amounts of epoxyeicosatrienoic acids (EETs), primarily 11,12 EETs.

Evidence that 20-HETE contributes to the development of acute and delayed cerebral vasospasm

Evidence that an elevation in the production of 20-HETE contributes to the initial fall in CBF following SAH and the later development of delayed vasospasm is examined.

Cytochrome P-450 monooxygenases in control of renal haemodynamics and arterial pressure in anaesthetized rats.

Total renal blood flow seems to be under vasodilator control of EETs whereas renal medullary perfusion under tonic suppression by 20-HETE, for the first in the whole kidney studies.

Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.

The role of 20-HETE in vascular dysfunction, inflammation, ischemic and hemorrhagic stroke and cardiac and renal ischemia reperfusion injury in the brain, kidney and heart is focused on.

Cytochrome P-450-dependent metabolism of arachidonic acid in the kidney of rats with diabetes insipidus.

The results indicate that the expression of CYP4A protein and the renal formation of 20-HETE are elevated in the kidney of BB rats due to a lack of vasopressin and that chronic blockade of the formation of20-HetE and EETs with ABT promotes water excretion in vasoppressin-deficient BB rats by reducing the circulating levels of oxytocin, which is a weak vasopressedin agonist.

20-hydroxyeicosatetraenoic acid and angiotensin: a positive feedback system to cause hypertension.

  • J. Imig
  • Biology, Medicine
    Hypertension
  • 2010
Significant evidence is provided that vascular 20-HETE levels increase in response to angiotensin II; however, the potential influence of 20- HETE on the renin-angiotens in system had not been previously investigated.

The Metabolites of Arachidonic Acid in Microvascular Function

Current research on pharmacological manipulation of certain components of the AA pathways (such as 20‐HETE production inhibition or prolongation of the life of epoxyeicoatrienoic acids(EETs) by inhibitors of soluble epoxide hydrolaze (sEH)promises effective therapy of cardiovascular and cerebrovascular diseases in the future.

Role of epoxyeicosatrienoic acids in renal functional response to inhibition of NO production in the rat.

It is concluded that NO tonically regulates epoxygenase activity and that EETs are renal vaosoconstrictors in vivo and contribute, at least in part, to the renal functional responses following inhibition of NO production.
...

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