P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate.

@article{Bhardwaj2000P450EA,
  title={P-450 epoxygenase and NO synthase inhibitors reduce cerebral blood flow response to N-methyl-D-aspartate.},
  author={A. Prasad Bhardwaj and Frances J. Northington and Juan Ricardo Carhuapoma and John R Falck and David R. Harder and Richard J. Traystman and Raymond C Koehler},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 4},
  pages={H1616-24}
}
Epoxyeicosatrienoic acids are cerebral vasodilators produced in astrocytes by cytochrome P-450 epoxygenase activity. The P-450 inhibitor miconazole attenuates the increase in cerebral blood flow (CBF) elicited by glutamate. We evaluated whether epoxygenase activity is involved in the CBF response to activation of the N-methyl-D-aspartate (NMDA) receptor… CONTINUE READING