P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells

@article{JingShao2011P450dependentEP,
  title={P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells},
  author={菁 JingShao邵 and Qiubai Li 李秋柏 and Hongxiang Wang 王红祥 and 芳 FangLiu刘 and Jiangang Jiang 蒋建刚 and Xiaojian Zhu 朱晓健 and Zhichao Chen 陈智超 and 萍 PingZou邹},
  journal={Journal of Huazhong University of Science and Technology [Medical Sciences]},
  year={2011},
  volume={31},
  pages={596-601}
}
P-450-dependent epoxygenase pathway of arachidonic acid and the products of epoxyeicosatrienoic acids (EETs) have been demonstrated to be involved in angiogenesis and tumor progression. This study examined the expression of EETs and the role of the pathway in the angiogenesis of multiple myeloma (MM). MM cell lines of U266 and RPMI8226 were cultured, and the EETs levels (11, 12-EET and 14, 15-EET) in the supernatant were determined by ELISA. Human umbilical vein endothelial cells (HUVECs) were… CONTINUE READING