P-4-15 Zotepine: Preclinical tests predict antipsychotic efficacy and an atypical profile

@article{Needham1995P415ZP,
  title={P-4-15 Zotepine: Preclinical tests predict antipsychotic efficacy and an atypical profile},
  author={Patricia L. Needham and Janette Atkinson and M. J. Skill and David J. Heal},
  journal={European Neuropsychopharmacology},
  year={1995},
  volume={5},
  pages={331-332}
}
Zotepine, an atypical antipsychotic structurally similar to clozapine, is in Phase III clinical trials in the United States and Europe for the treatment and management of acute and chronic schizophrenia. Zotepine's pharmacological profile has been compared with those of the atypical antipsychotic clozapine, and the typical neuroleptics haloperidol and chlorpromazine in preclinical tests that predict antipsychotic efficacy and extrapyramidal symptoms (EPS). Because zotepine causes potent, long… CONTINUE READING

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