P/Q Ca2+ channels are functionally coupled to exocytosis of the immediately releasable pool in mouse chromaffin cells.

@article{lvarez2008PQCC,
  title={P/Q Ca2+ channels are functionally coupled to exocytosis of the immediately releasable pool in mouse chromaffin cells.},
  author={Yanina D. {\'A}lvarez and Lorena Itat{\'i} Iba{\~n}ez and Osvaldo Daniel Uchitel and Fernando D. Marengo},
  journal={Cell calcium},
  year={2008},
  volume={43 2},
  pages={155-64}
}
Chromaffin cell exocytosis is triggered by Ca(2+) entry through several voltage-dependent channel subtypes. Because it was postulated that immediately releasable vesicles are closely associated with Ca(2+) channels, we wondered what channel types are specifically coupled to the release of this pool. To study this question, cultured mouse chromaffin cell exocytosis was followed by patch-clamp membrane capacitance measurements. The immediately releasable pool was estimated using paired pulse… CONTINUE READING

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