Ozone therapy in 65 patients with fibromyalgia: an effective therapy.

  title={Ozone therapy in 65 patients with fibromyalgia: an effective therapy.},
  author={Umberto Tirelli and Cinzia Cirrito and Martina Pavanello and Christian Piasentin and Arben Lleshi and Rosaria Taibi},
  journal={European review for medical and pharmacological sciences},
  volume={23 4},
OBJECTIVE Fibromyalgia is a chronic disorder with a very complex symptomatology. Although generalized severe pain is considered to be the cardinal symptom of the disease, many other associated symptoms, especially non-restorative sleep, chronic fatigue, anxiety, and depressive symptoms also play a relevant role in the degree of disability characteristic of the disease. Ozone therapy, which is used to treat a wide range of diseases and seems to be particularly useful in the treatment of many… 

The effectiveness of major ozone autohemotherapy in the treatment of fibromyalgia syndrome

Evaluating the effectiveness of major autohemotherapy with ozone applied twice a week for Fibromyalgia syndrome found it to be an effective and practical method in the treatment of FMS.

Comparison of Drug and Non-Drug Treatment Options of Fibromyalgia

The challenge of achieving adequate pain control without adverse side effects further compounds the problem and provides rationale for seeking complementary medicine and non-medicine alternatives.

Oxygen-Ozone Therapy is an Effective Therapy in Chronic Fatigue Syndrome: Results in 100 Patients

  • U. Tirelli
  • Medicine, Psychology
    Biomedical Journal of Scientific & Technical Research
  • 2019
The myalgic encephalomyelitis and the chronic fatigue syndrome (ME/CFS), are described as a multifaceted physical complaint that often suffers for incapacitating fatigue, massive energy crashes after minor exertion, tenderness, cognitive problems, sleeping disorders and many other neurological, immunological and autonomic symptoms.

Uma revisão sistemática da literatura sobre os efeitos da ozonioterapia nos pacientes com fibromialgia: resultados clínicos / A systematic literature review of the effects of ozone therapy in patients with fibromyalgia: clinical outcomes

It is concluded that the existing evidence is insufficient to indicate ozone therapy as an effective and safe treatment in the long and/or short term for those with fibromyalgia.

The possibilities of using the effects of ozone therapy in neurology.

Clinical studies on O2-O3 therapy have been shown to be efficient in the treatment of neurological degenerative disorders, multiple sclerosis, cardiovascular, peripheral vascular, orthopedic, gastrointestinal and genitourinary pathologies, fibromyalgia, skin diseases/wound healing, diabetes/ulcers, infectious diseases, and lung diseases, including the pandemic disease caused by the COVID-19 coronavirus.

Case Report Oxygen-Ozone Therapy in Rheumatic Symptoms in 3 Patients with Breast Cancer Undergoing Aromatase-Inhibitors: A Successful Approach

Oxygen-ozone therapy, in the management of rheumatic symptoms in patients with breast cancer undergoing aromatase inhibitors, showed to be efficient with no side effected associated with its use.

Oxygen–Ozone Therapy in the Rehabilitation Field:State of the Art on Mechanisms of Action, Safety andEffectiveness in Patients with Musculoskeletal Disorders

It is suggested that O2O3 therapy seems to reduce pain and improve functioning in patients affected by low back pain and knee osteoarthritis, as reported by several studies in the literature.

Adjuvant Treatments for CRPS

There was a paucity of literature investigating the use of nonconventional therapies for CRPS, suggesting the need for further evidence-based research in this area.

Expert consensus on the diagnosis and treatment of myofascial pain syndrome

The consensus is intended to normalize the diagnosis and treatment of MPS and be used by first-line doctors, including pain physicians to manage patients with MPS.

The Mito-Hormetic Mechanisms of Ozone in the Clearance of SARS-CoV2 and in the COVID-19 Therapy

The molecular mechanisms through which medical ozone acts are described, the clinical evidence on the use of O2–O3 therapy as an alternative and adjuvant COVID-19 treatment is summarized, and the emerging potential of this approach is discussed in the context of PASC symptoms, thus offering new insights into effective and safe nonantiviral therapies for the fighting of this devastating pandemic.



Psychosocial aspects of chronic widespread pain and fibromyalgia

  • S. Bergman
  • Medicine
    Disability and rehabilitation
  • 2005
The spectrum of impact on health and association to background variables, with respect to a stricter definition of CWP, indicates that these factors are important to attend to in the understanding and management ofCWP and FM.

Clinical characteristics of fibrositis. I. A "blinded," controlled study of symptoms and tender points.

Using the criteria of this study, fibrositis appears to be a common and readily definable syndrome within the spectrum of soft tissue rheumatism.

Comparison of pain properties in fibromyalgia patients and rheumatoid arthritis patients.

The traditional clinical description of aching and stiffness does not appear to accurately describe the complexity of the fibromyalgia pain syndrome.

Oxygen-ozone therapy as support and palliative therapy in 50 cancer patients with fatigue - A short report.

The preliminary data demonstrate that ozone therapy is a valid supportive therapy for fatigue in cancer patients, both during cancer therapy and in a palliative setting with no significant side effects.

The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee.

Criteria for the classification of fibromyalgia are widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites, and no exclusions are made for the presence of concomitant radiographic or laboratory abnormalities.

Atypical chest pain as an initial presentation of primary fibromyalgia.

  • M. Pellegrino
  • Medicine
    Archives of physical medicine and rehabilitation
  • 1990
Four patients with atypical chest pain initially believed to be cardiac in origin were subsequently found to have primary fibromyalgia, and the diagnosis was confirmed by demonstrating muscle tender and trigger points which reproduced the chest symptoms.

Use of Complementary and Alternative Medicine (CAM) in cancer patients: An Italian multicenter survey

It is necessary that health professional explore the use of CAM with their cancer patients, educate them about potentially beneficial therapies in light of the limited available evidence of effectiveness, and work towards an integrated model of health-care provision.

Sex Differences in Glucocorticoid Sensitivity of Proinflammatory Cytokine Production After Psychosocial Stress

Investigating the impact of psychosocial stress and HPA axis activation on the GC sensitivity of proinflammatory cytokine production in men and women demonstrates that despite similar free cortisol responses of men andWomen (studied in the luteal phase of their menstrual cycle) to psychossocial stress, gender may exert differential effects on the immune system by modulating GC sensitivity.