Ozone induces oxidative stress in rat alveolar type II and type I-like cells.

@article{Wang2006OzoneIO,
  title={Ozone induces oxidative stress in rat alveolar type II and type I-like cells.},
  author={Jieru Wang and Shuanglin Wang and Rizwan Manzer and G. Mcconville and Robert J. Mason},
  journal={Free radical biology & medicine},
  year={2006},
  volume={40 11},
  pages={1914-28}
}
Ozone is a highly reactive gas present in urban air, which penetrates deep into the lung and causes lung injury. The alveolar epithelial cells are among the first cell barriers encountered by ozone. To define the molecular basis of the cellular response to ozone, primary cultures of rat alveolar type II and type I-like cells were exposed to 100 ppb ozone or air for 1 h. The mRNA from both phenotypes was collected at 4 and 24 h after exposure for gene expression profiling. Ozone produced… CONTINUE READING