Ozone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum.

@article{Thiele1997OzoneexposureDV,
  title={Ozone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum.},
  author={Jens J. Thiele and Maret G Traber and Thomas G. Polefka and Carroll E. Cross and Lester Packer},
  journal={The Journal of investigative dermatology},
  year={1997},
  volume={108 5},
  pages={
          753-7
        }
}
The presence of ozone (O(3)) in photochemical smog is an important health concern. We hypothesized that the stratum corneum (SC), as the outermost skin layer and the permeability barrier of the skin, represents a sensitive target for O(3)-induced oxidative stress. To test this hypothesis, SKH-1 hairless mice were anesthetized and exposed for 2 h to O(3) by using two strategies: (i) single exposures to 0 (n = 12), 1 (n = 4), 5 (n = 4), and 10 (n = 4) ppm; and (ii) repeated daily exposures to 0… CONTINUE READING

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