Oxytocin signaling in basolateral and central amygdala nuclei differentially regulates the acquisition, expression, and extinction of context-conditioned fear in rats.

@article{CampbellSmith2015OxytocinSI,
  title={Oxytocin signaling in basolateral and central amygdala nuclei differentially regulates the acquisition, expression, and extinction of context-conditioned fear in rats.},
  author={Emma J Campbell-Smith and Nathan M. Holmes and Nura W. Lingawi and Marios C Panayi and Reginald Frederick Westbrook},
  journal={Learning & memory},
  year={2015},
  volume={22 5},
  pages={247-57}
}
The present study investigated how oxytocin (OT) signaling in the central (CeA) and basolateral (BLA) amygdala affects acquisition, expression, and extinction of context-conditioned fear (freezing) in rats. In the first set of experiments, acquisition of fear to a shocked context was impaired by a preconditioning infusion of synthetic OT into the CeA (Experiment 1) or BLA (Experiment 2). In the second set of experiments, expression of context fear was enhanced by a pre- or post-extinction CeA… CONTINUE READING