Oxytocin reduces intravenous heroin self-administration in heroin-tolerant rats.

@article{Kovcs1985OxytocinRI,
  title={Oxytocin reduces intravenous heroin self-administration in heroin-tolerant rats.},
  author={G{\'a}bor L{\'a}szl{\'o} Kov{\'a}cs and Z Borthaiser and Gyula Telegdy},
  journal={Life sciences},
  year={1985},
  volume={37 1},
  pages={
          17-26
        }
}
Intravenous self-administration of heroin was studied in experimentally naive rats, as compared to this behavior in animals rendered tolerant to heroin by multiple injections. The tolerant rats also exhibited mild signs of spontaneous and naloxone-precipitated heroin withdrawal. Self-administration behavior developed earlier in the tolerant rats. In heroin-naive rats, oxytocin treatment did not influence the acquisition of heroin self-administration behavior. In the tolerant rats, on the other… CONTINUE READING

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