Oxytocin receptor-deficient mice developed late-onset obesity.

@article{Takayanagi2008OxytocinRM,
  title={Oxytocin receptor-deficient mice developed late-onset obesity.},
  author={Yoshio Takayanagi and Yoshiyuki Kasahara and Tatsushi Onaka and Nobuyuki Takahashi and Tomoyuki Kawada and Katsuhiko Nishimori},
  journal={Neuroreport},
  year={2008},
  volume={19 9},
  pages={
          951-5
        }
}
The oxytocin receptor has been suggested to be involved in energy metabolism, such as food intake and energy consumption. Here, we demonstrate that oxytocin receptor-deficient (Oxtr-/-) male mice exhibited late-onset obesity with increases in abdominal fat pads and fasting plasma triglycerides. Daily food intake and spontaneous motor activity of Oxtr-/- mice were not significantly different as compared with wild-type mice. In contrast, brown adipose tissue in Oxtr-/- mice contained large lipid… CONTINUE READING
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