Oxytocin opposes effects of bacterial endotoxin on ER-stress signaling in Caco2BB gut cells.

@article{Klein2016OxytocinOE,
  title={Oxytocin opposes effects of bacterial endotoxin on ER-stress signaling in Caco2BB gut cells.},
  author={Benjamin Y. Klein and Hadassah Tamir and David L. Hirschberg and Robert J. Ludwig and Sara B. Glickstein and Michael M. Myers and Martha G Welch},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1860 2},
  pages={
          402-11
        }
}

• Benjamin Y. Klein, Hadassah Tamir, +4 authors Martha G Welch
• Published in Biochimica et biophysica acta 2016
• DOI:10.1016/j.bbagen.2015.10.025

BACKGROUND The neuropeptide neuromodulator and hormone oxytocin (OT) activates signaling pathways involved in mRNA translation in response to endoplasmic reticulum stress and reduces inflammation associated with experimental colitis in rats. The anti-inflammatory effects of OT may serve a vital role in the development, survival and function of newborn-type enterocytes during microbial gut colonization, which coincides with the milk suckling period when OT receptor expression peaks in the gut… CONTINUE READING

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