Oxytocin modulates estrogen receptor alpha expression and function in MCF7 human breast cancer cells.

@article{Cassoni2002OxytocinME,
  title={Oxytocin modulates estrogen receptor alpha expression and function in MCF7 human breast cancer cells.},
  author={Paola Cassoni and Maria Graziella Catalano and Anna Sapino and Tiziana Marrocco and Annamaria Fazzari and Gianni Bussolati and Nicoletta Fortunati},
  journal={International journal of oncology},
  year={2002},
  volume={21 2},
  pages={375-8}
}
Oxytocin (OT) inhibits the proliferation of MCF7 estrogen-dependent human breast cancer cells, via specific OT receptors (OTR). Besides this effect, we report that OT modulates the expression of estrogen receptor alpha (ERalpha) in MCF7 cells, both at mRNA and protein level. Since the first 24 h of OT treatment the ERalpha mRNA levels are down-regulated; in contrast, ERalpha protein expression decreases at a later time. The reduced number of ERalpha goes in parallel to a temporary increase in… CONTINUE READING
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