Oxytocin mediates stress-induced analgesia in adult mice.

  title={Oxytocin mediates stress-induced analgesia in adult mice.},
  author={Daphn{\'e} A Robinson and Feng Wei and Guo Du Wang and Ping Li and Sang Jeong Kim and Sherri K. Vogt and Louis J. Muglia and Min Zhuo},
  journal={The Journal of physiology},
  volume={540 Pt 2},
As a neurohormone and as a neurotransmitter, oxytocin has been implicated in the stress response. Descending oxytocin-containing fibres project to the dorsal horn of the spinal cord, an area important for processing nociceptive inputs. Here we tested the hypothesis that oxytocin plays a role in stress-induced analgesia and modulates spinal sensory transmission. Mice lacking oxytocin exhibited significantly reduced stress-induced antinociception following both cold-swim (10 degrees C, 3 min) and… CONTINUE READING


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