Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition

@article{Breton2008OxytocininducedAI,
  title={Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition},
  author={Jean Didier Breton and Pierre Veinante and Sandra Uhl-Bronner and Angela Maria Vergnano and Marie Jos{\'e} Freund-Mercier and R{\'e}my Schlichter and Pierrick Poisbeau},
  journal={Molecular Pain},
  year={2008},
  volume={4},
  pages={19 - 19}
}
BACKGROUND Recent evidence suggests that oxytocin (OT), secreted in the superficial spinal cord dorsal horn by descending axons of paraventricular hypothalamic nucleus (PVN) neurons, produces antinociception and analgesia. The spinal mechanism of OT is, however, still unclear and requires further investigation. We have used patch clamp recording of lamina II neurons in spinal cord slices and immunocytochemistry in order to identify PVN-activated neurons in the superficial layers of the spinal… CONTINUE READING
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