Oxytocin increases amygdala reactivity to threatening scenes in females

@article{Lischke2012OxytocinIA,
  title={Oxytocin increases amygdala reactivity to threatening scenes in females},
  author={Alexander Lischke and M. Gamer and C. Berger and A. Grossmann and G. Domes},
  journal={Psychoneuroendocrinology},
  year={2012},
  volume={37},
  pages={1431-1438}
}
  • Alexander Lischke, M. Gamer, +2 authors G. Domes
  • Published 2012
  • Psychology, Medicine
  • Psychoneuroendocrinology
  • The neuropeptide oxytocin (OT) is well known for its profound effects on social behavior, which appear to be mediated by an OT-dependent modulation of amygdala activity in the context of social stimuli. In humans, OT decreases amygdala reactivity to threatening faces in males, but enhances amygdala reactivity to similar faces in females, suggesting sex-specific differences in OT-dependent threat-processing. To further explore whether OT generally enhances amygdala-dependent threat-processing in… CONTINUE READING
    168 Citations

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Positive results in preclinical and clinical studies in adults and infants with Prader-Willi syndrome lead investigators to set up a new study in children with Prader-Willi syndrome. The… Expand
    ConditionsPrader-Willi Syndrome
    InterventionDrug
    INTERVENTIONAL CLINICAL TRIAL
    The objective of this study is to collect data on tolerance and effects of early treatment with oxytocin in children with Prader Willi Syndrome aged from 3 to 4 years and to compare… Expand
    ConditionsPrader-Willi Syndrome
    InterventionDrug, Other
    Oxytocin facilitates protective responses to aversive social stimuli in males
    • 193
    • PDF
    Oxytocin modulates fMRI responses to facial expression in macaques
    • 45
    • PDF
    Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men
    • 12
    Divergent effects of oxytocin on (para-)limbic reactivity to emotional and neutral scenes in females with and without borderline personality disorder
    • 16
    • PDF
    Oxytocinergic modulation of brain activation to cues related to reproduction and attachment: Differences and commonalities during the perception of erotic and fearful social scenes.
    • C. Sauer, C. Montag, M. Reuter, P. Kirsch
    • Psychology, Medicine
    • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
    • 2019
    • 3
    Oxytocin reduces amygdala responses during threat approach
    • 37
    • PDF
    Oxytocin Enhances the Neural Efficiency of Social Perception
    • 4
    • PDF
    Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients
    • 54
    • PDF
    Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
    • 74
    • PDF

    References

    SHOWING 1-10 OF 51 REFERENCES
    Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence
    • 672
    • PDF
    Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
    • 1,340
    • Highly Influential
    • PDF
    Effects of intranasal oxytocin on emotional face processing in women
    • 435
    • PDF
    Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
    • 395
    • PDF
    Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
    • 397
    • Highly Influential
    • PDF
    Oxytocin increases recognition of masked emotional faces
    • 142
    Oxytocin Enhances the Encoding of Positive Social Memories in Humans
    • 317
    Effects of Oxytocin and Prosocial Behavior on Brain Responses to Direct and Vicariously Experienced Pain
    • 216
    • PDF
    Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers
    • 217