Oxytocin increases amygdala reactivity to threatening scenes in females

@article{Lischke2012OxytocinIA,
  title={Oxytocin increases amygdala reactivity to threatening scenes in females},
  author={A. Lischke and M. Gamer and C. Berger and A. Grossmann and Karlheinz Hauenstein and M. Heinrichs and S. Herpertz and G. Domes},
  journal={Psychoneuroendocrinology},
  year={2012},
  volume={37},
  pages={1431-1438}
}
The neuropeptide oxytocin (OT) is well known for its profound effects on social behavior, which appear to be mediated by an OT-dependent modulation of amygdala activity in the context of social stimuli. In humans, OT decreases amygdala reactivity to threatening faces in males, but enhances amygdala reactivity to similar faces in females, suggesting sex-specific differences in OT-dependent threat-processing. To further explore whether OT generally enhances amygdala-dependent threat-processing in… Expand

Paper Mentions

Interventional Clinical Trial
Positive results in preclinical and clinical studies in adults and infants with Prader-Willi syndrome lead investigators to set up a new study in children with Prader-Willi syndrome… Expand
ConditionsPrader-Willi Syndrome
InterventionDrug
Interventional Clinical Trial
The objective of this study is to collect data on tolerance and effects of early treatment with oxytocin in children with Prader Willi Syndrome aged from 3 to 4 years and to compare… Expand
ConditionsPrader-Willi Syndrome
InterventionDrug, Other
Oxytocin facilitates protective responses to aversive social stimuli in males
TLDR
Results show that OXT can potentiate the protective and mnemonic impact of aversive social information despite reducing amygdala activity, and suggest that the insula may play a role in emotional modulation of memory. Expand
Oxytocin modulates fMRI responses to facial expression in macaques
TLDR
In monkeys, OT selectively altered brain activity within multiple neural systems and functional coupling between the amygdala and areas in the ventral visual pathway evoked by negative emotional expressions and this results indicate homologies between monkeys and humans in the neural circuits mediating the effects of OT. Expand
Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men
TLDR
The findings suggest that OXT increases the salience of social signals by strengthening the sensitivity for these signals in the amygdala and in the striatum in women, while OXT may primarily induce anxiolysis by reducing amygdala responses in men. Expand
Divergent effects of oxytocin on (para-)limbic reactivity to emotional and neutral scenes in females with and without borderline personality disorder
TLDR
The findings suggest that oxytocin may be capable of attenuating BPD patients’ hypersensitivity for complex scenes, irrespective of their valence. Expand
Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces
TLDR
It is demonstrated that OXT produces sex‐dependent effects even at the early stages of social‐emotional processing, and suggested that while it attenuates neural responses to threatening social stimuli in men it increases them in women. Expand
Oxytocinergic modulation of brain activation to cues related to reproduction and attachment: Differences and commonalities during the perception of erotic and fearful social scenes.
  • C. Sauer, C. Montag, M. Reuter, P. Kirsch
  • Psychology, Medicine
  • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2019
TLDR
While OT administration led to a relative increase of neural activation in mesolimbic structures during processing of erotic stimuli, it decreased amygdala activation for fearful stimuli, and significant positive correlations between OT induced activation changes across different brain regions and under different stimulus conditions are observed. Expand
Oxytocin reduces amygdala responses during threat approach
TLDR
Oxytocin decreased amygdala activation during threat approach and not during threat avoidance, which supports oxytocin's social anxiolytic effects and provides a neuroendocrine mechanism promoting social approach. Expand
Oxytocin Enhances the Neural Efficiency of Social Perception
TLDR
Findings suggest OT modulates early stages of social perception for socially complex information such as emotional faces relative to neutral, consistent with models suggesting OT impacts the salience of socially informative cues during processing, which leads to downstream effects in behavior. Expand
Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients
TLDR
Results indicate presumably beneficial neurobiological effects of OT administration in male and female PTSD patients and should be investigated in clinical settings to fully appreciate its therapeutic potential. Expand
Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
TLDR
It is tentatively suggested that OT has the potential to diminish anxiety and fear expression of the amygdala in PTSD, either via increased control of the vmPFC over the CeM (males) or via decreased salience processing of the dACC and BLA (females). Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 51 REFERENCES
Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence
TLDR
A modulatory role of oxytocin on amygdala responses to facial expressions irrespective of their valence is suggested, which might reflect reduced uncertainty about the predictive value of a social stimulus and thereby facilitates social approach behavior. Expand
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
TLDR
It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism. Expand
Effects of intranasal oxytocin on emotional face processing in women
TLDR
Group analysis revealed that the blood-oxygen-level-dependent signal was enhanced in the left amygdala, the fusiform gyrus and the superior temporal gyrus in response to fearful faces and in the inferior frontal gyrus following OXT treatment, independent of fixation pattern to specific sections of the facial stimuli. Expand
Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
TLDR
Different behavioral effects of oxytocin seem to be closely related its specific modulatory influence on subregions within the human amygdala. Expand
Oxytocin Attenuates Affective Evaluations of Conditioned Faces and Amygdala Activity
TLDR
The data suggest that oxytocin modulates the expression of evaluative conditioning for socially relevant faces via influences on amygdala and fusiform gyrus, an effect that may explain its prosocial effects. Expand
Oxytocin increases recognition of masked emotional faces
TLDR
Evidence is provided that a single dose of intranasally administered oxytocin enhances detection of briefly presented emotional stimuli and was more pronounced for the recognition of happy faces. Expand
Oxytocin Enhances the Encoding of Positive Social Memories in Humans
TLDR
Results suggest that oxytocin could enhance social approach, intimacy, and bonding in male humans by strengthening encoding to make the recall of positive social information more likely. Expand
The effect of intranasal administration of oxytocin on fear recognition
TLDR
A single intranasal administration of oxytocin, as opposed to the placebo, improved the subjects' ability to recognize fear, but not other emotions, suggesting a specific role for oxytoc in fear recognition, which could be relevant for clinical disorders that manifest deficits in processing emotional facial expressions, particularly fear. Expand
Effects of Oxytocin and Prosocial Behavior on Brain Responses to Direct and Vicariously Experienced Pain
TLDR
The results suggest that selfish individuals may not be as rational and unemotional as usually suggested, their actions being determined by their feeling anxious rather than by reason. Expand
Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers
TLDR
It is suggested that oxytocin modulates emotion processing in healthy male volunteers, which may contribute to the emerging role of the neuropeptide in promoting affiliative and approach behaviours by reducing the salience of potentially ambiguous and threatening social stimuli. Expand
...
1
2
3
4
5
...