Oxytocin in the medial prefrontal cortex attenuates anxiety: Anatomical and receptor specificity and mechanism of action.

@article{Sabihi2017OxytocinIT,
  title={Oxytocin in the medial prefrontal cortex attenuates anxiety: Anatomical and receptor specificity and mechanism of action.},
  author={Sara Sabihi and Shirley M. Dong and Skyler D Maurer and Caitlin Post and Benedetta Leuner},
  journal={Neuropharmacology},
  year={2017},
  volume={125},
  pages={
          1-12
        }
}
Numerous studies in animals and humans have established that oxytocin (OT) reduces anxiety. In rats, the prelimbic (PL) subregion of the medial prefrontal cortex (mPFC) is among the brain areas implicated in the anxiolytic actions of OT. However, questions remain about the anatomical and receptor specificity of OT and its mechanism of action. Here we assessed whether the regulation of anxiety by mPFC OT is restricted to the PL subregion and evaluated whether oxytocin receptor (OTR) activation… CONTINUE READING