Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway.

@article{Che2012OxytocinHC,
  title={Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BK(Ca) channels through IP₃ pathway.},
  author={Tongtong Che and Hui Sun and Jing Xin Li and Xiao Tong Yu and Dexiao Zhu and Bing Xue and Kejing Liu and Min Zhang and Wolfgang Kunze and Chuanyong Liu},
  journal={Journal of neurochemistry},
  year={2012},
  volume={121 4},
  pages={516-25}
}
Oxytocin (OT) is clinically important in gut motility and constitutively reduces duodenum contractility. Intrinsic primary afferent neurons (IPANs), whose physiological classification is as AH cells, are the 1st neurons of the peristaltic reflex pathway. We set out to investigate if this inhibitory effect is mediated by IPANs and to identify the ion channel(s) and intracellular signal transduction pathway that are involved in this effect. Myenteric neurons were isolated from the longitudinal… CONTINUE READING

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