Oxytocin facilitates the extinction of conditioned fear in humans.

@article{Eckstein2015OxytocinFT,
  title={Oxytocin facilitates the extinction of conditioned fear in humans.},
  author={Monika Eckstein and Benjamin Becker and Dirk Scheele and Claudia Scholz and Katrin Preckel and Thomas E. Schlaepfer and Valery Grinevich and Keith M. Kendrick and Wolfgang Maier and Ren{\'e} Hurlemann},
  journal={Biological psychiatry},
  year={2015},
  volume={78 3},
  pages={194-202}
}
BACKGROUND Current neurocircuitry models of anxiety disorders posit a lack of inhibitory tone in the amygdala during acquisition of Pavlovian fear responses and deficient encoding of extinction responses in amygdala-medial prefrontal cortex circuits. Competition between these two responses often results in a return of fear, limiting control over anxiety. However, one hypothesis holds that a pharmacologic strategy aimed at reducing amygdala activity while simultaneously augmenting medial… CONTINUE READING

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Current neurocircuitry models of anxiety disorders posit a lack of inhibitory tone in the amygdala during acquisition of Pavlovian fear responses and deficient encoding of extinction responses in amygdala - medial prefrontal cortex circuits .
However , one hypothesis holds that a pharmacologic strategy aimed at reducing amygdala activity while simultaneously augmenting medial prefrontal cortex function could facilitate the extinction of conditioned fear . METHODS .
Current neurocircuitry models of anxiety disorders posit a lack of inhibitory tone in the amygdala during acquisition of Pavlovian fear responses and deficient encoding of extinction responses in amygdala - medial prefrontal cortex circuits .
Oxytocin , when administered intranasally after Pavlovian fear conditioning , was found to increase electrodermal responses and prefrontal cortex signals to conditioned fear in the early phase of extinction and to enhance the decline of skin conductance responses in the late phase of extinction .
Oxytocin , when administered intranasally after Pavlovian fear conditioning , was found to increase electrodermal responses and prefrontal cortex signals to conditioned fear in the early phase of extinction and to enhance the decline of skin conductance responses in the late phase of extinction .
Oxytocin , when administered intranasally after Pavlovian fear conditioning , was found to increase electrodermal responses and prefrontal cortex signals to conditioned fear in the early phase of extinction and to enhance the decline of skin conductance responses in the late phase of extinction .
Oxytocin , when administered intranasally after Pavlovian fear conditioning , was found to increase electrodermal responses and prefrontal cortex signals to conditioned fear in the early phase of extinction and to enhance the decline of skin conductance responses in the late phase of extinction .
However , one hypothesis holds that a pharmacologic strategy aimed at reducing amygdala activity while simultaneously augmenting medial prefrontal cortex function could facilitate the extinction of conditioned fear . METHODS .
Current neurocircuitry models of anxiety disorders posit a lack of inhibitory tone in the amygdala during acquisition of Pavlovian fear responses and deficient encoding of extinction responses in amygdala - medial prefrontal cortex circuits .
Current neurocircuitry models of anxiety disorders posit a lack of inhibitory tone in the amygdala during acquisition of Pavlovian fear responses and deficient encoding of extinction responses in amygdala - medial prefrontal cortex circuits .
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