Oxytocin blocks the development of heroin-fentanyl cross-tolerance in mice.

Abstract

The development of cross-tolerance to an analgesic effect was observed between two mu-receptor agonists, heroin and fentanyl. Repeated treatments with heroin twice a day for 4 days resulted in a decreased nociceptive effect to fentanyl on day 5. The fentanyl dose-response line shifted to the right, and was considered to be a sign of the development of cross… (More)

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Cite this paper

@article{Krivn1995OxytocinBT, title={Oxytocin blocks the development of heroin-fentanyl cross-tolerance in mice.}, author={M Kriv{\'a}n and G y Szab{\'o} and Zsolt Sarnyai and G{\'a}bor L{\'a}szl{\'o} Kov{\'a}cs and Gyula Telegdy}, journal={Pharmacology, biochemistry, and behavior}, year={1995}, volume={52 3}, pages={591-4} }