Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition.

@article{Macbeth2009OxytocinAT,
  title={Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition.},
  author={Abbe H Macbeth and Hyun-Joo Lee and Jennifer Stepp Edds and W Scott Young},
  journal={Genes, brain, and behavior},
  year={2009},
  volume={8 5},
  pages={558-67}
}
We studied three lines of oxytocin (Oxt) and oxytocin receptor (Oxtr) knockout (KO) male mice [Oxt(-/-), total Oxtr(-/-) and partial forebrain Oxtr (Oxtr(FB/FB))] with established deficits in social recognition to further refine our understanding of their deficits with regard to stimulus female's strain. We used a modified social discrimination paradigm in which subjects are singly housed only for the duration of the test. Additionally, stimulus females are singly housed throughout testing and… CONTINUE READING

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