Oxytocin and its analogs, methyl-substituted in ortho-, meta- or para-position of aromatic ring of phenylalanine in position 2: NMR study and biological activities.

Abstract

Complete analyses of NMR data of oxytocin (OT) and 4 analogues, ([o-MePhe(2)]OT, [mMe-Phe(2)]OT, [m-OMePhe(2)]OT and [p-MePhe(2)]OT), are given. The same conformational behavior in solution on one hand and large differences in biological activities on the other hand indicate that the compounds adopt a "biologically active conformation" at the stage of… (More)

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Cite this paper

@article{Budnsk2005OxytocinAI, title={Oxytocin and its analogs, methyl-substituted in ortho-, meta- or para-position of aromatic ring of phenylalanine in position 2: NMR study and biological activities.}, author={Milo{\vs} Budě{\vs}{\'i}nsk{\'y} and Zdenko Proch{\'a}zka and Jiřina Slaninov{\'a}}, journal={Protein and peptide letters}, year={2005}, volume={12 4}, pages={343-7} }