Corpus ID: 6320740

Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists.

@article{Klenerova2009OxytocinAC,
  title={Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists.},
  author={Vera Klenerova and Ivan Krejci and Pavel {\vS}ı́da and Zdeněk Hliň{\'a}k and Sixtus Hynie},
  journal={Neuro endocrinology letters},
  year={2009},
  volume={30 3},
  pages={
          335-42
        }
}
OBJECTIVES Oxytocin (OXY) in addition to peripheral actions has many central regulatory functions which can be studied on animal models. In the present study we examined in rats, which behavioral actions of OXY and long-acting carba-analog of OXY carbetocin (CBT) in the open-field can be inhibited by OXY-receptor antagonists. Our interest focused on the behavioral patterns considered indicative of anxiety-related behavior. To determine what is the participation of OXY receptor on OXY and CBT… Expand

Paper Mentions

Observational Patient Registry Clinical Trial
The aim of this study was to assess whether administration of oxytocin intrapartum (Oxt) has any effect on Neonatal Primitive Reflexes (RNP) and if dose dependent. The secondary… Expand
ConditionsBonding, Breastfeeding, Newborn, (+2 more)
InterventionDrug
Oxytocin and carbetocin ameliorating effects on restraint stress-induced short- and long-term behavioral changes in rats.
TLDR
The CBT effectiveness to ameliorate the late post-stress behavioral alteration supports the notion of its therapeutic potential in psychiatric disorders in which the role of OXY has been implicated. Expand
Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats
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Systemic oxytocin administration attenuated phencyclidine-induced hyperactivity and increased pro-social behavior without decreasing core body temperature and selectively enhanced nucleus accumbens dopamine release, consistent with activation of mesocorticolimbic circuits regulating associative/reward behavior being involved. Expand
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The facilitation of BN PPI by oxytocin is similar to what has been observed with clozapine and thus further supports oxytoc in having antipsychotic properties, and the use of carbetocin as an antipsychotics drug is not supported. Expand
Effects of intracerebroventricularly administered carbetocin on social behavior in Holstein steers.
TLDR
The results suggest that central OXT receptor activation might not affect social behavior itself among "familiar members", because the stimulation of the central Oxt system by intracerebroventricular administration of CBT did not facilitate social behavior between familiar steers. Expand
Involvement of nigral oxytocin in locomotor activity: A behavioral, immunohistochemical and lesion study in male rats
TLDR
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Galanin modulating effect on restraint stress-induced short- and long-term behavioral changes in Wistar rats
TLDR
The results demonstrate that behavioral effects of the peptide galanin are evident even after i.p. administration, and support the notion that the galan inergic system may serve as a drug target in stress-related conditions. Expand
Proconvulsive effects of oxytocin in the generalized pentylenetetrazol mouse model are mediated by vasopressin 1a receptors
TLDR
Oxytocin has proconvulsive effects in the mouse model of generalized seizures that could not be mimicked by CBT, and the binding of OT to V1aRs is the most plausible explanation for the proconvulsion effects of OT. Expand
Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats
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Overall these results suggest that exogenous OT administered during adolescence can have subtle yet enduring effects on anxiety, sociability and the motivation to consume alcohol. Expand
alanin modulating effect on restraint stress-induced short-and long-term ehavioral changes in Wistar rats era
The neuropeptide galanin has been recognized as a possible neurotransmitter/neuromodulator, and in addition has been implicated in anxietyand depression-related behaviors. The present studyExpand
Selective and non-selective OT receptor agonists induce different locomotor behaviors in male rats via central OT receptors and peripheral V1a receptors
TLDR
These findings identify distinct behavioral effects for OT and the selective agonist FE 204409, adding to the growing body of evidence that the V1aR mediates many effects attributed to OT and that peptides administered systemically at supra-physiological doses may activate receptors in the brain. Expand
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