Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain.

@article{Kovcs1985OxytocinAA,
  title={Oxytocin and a C-terminal derivative (Z-prolyl-D-leucine) attenuate tolerance to and dependence on morphine and interact with dopaminergic neurotransmission in the mouse brain.},
  author={G. L. Kov{\'a}cs and Zolt{\'a}n Horv{\'a}th and Zoltan Sarnyai and M{\'a}ria Faludi and Gyula Telegdy},
  journal={Neuropharmacology},
  year={1985},
  volume={24 5},
  pages={413-9}
}
The effects of oxytocin (OXT) and of dipeptides derived from the C-terminal portion of oxytocin (Z-prolyl-leucine and Z-prolyl-D-leucine) on the development of acute and chronic tolerance to, and dependence on morphine were tested in the mouse. Oxytocin and the dipeptides attenuated the development of acute and chronic tolerance to the antinociceptive… CONTINUE READING