Oxytocin acts as an antidepressant in two animal models of depression.

@article{Arletti1987OxytocinAA,
  title={Oxytocin acts as an antidepressant in two animal models of depression.},
  author={Rossana Arletti and Alfio Bertolini},
  journal={Life sciences},
  year={1987},
  volume={41 14},
  pages={
          1725-30
        }
}
In the behavioral despair test in mice, oxytocin, i.p. injected 60 min before testing, significantly reduced the duration of immobility at doses of 0.250-1.0 mg/Kg; the effect being similar to that of imipramine (7.5-30 mg/Kg i.p.). A more powerful effect was obtained with a 10-day treatment schedule. In the learned helplessness test, oxytocin (0.500 mg/Kg… CONTINUE READING