Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

@article{Viviani2011OxytocinSG,
  title={Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala},
  author={Daniele Viviani and Alexandre Charlet and Erwin H. van den Burg and Camille Robinet and Nicolas Hurni and Marios Abatis and Fulvio Magara and Ron Stoop},
  journal={Science},
  year={2011},
  volume={333},
  pages={104 - 107}
}
Specific neuronal populations in the amygdala control different behavioral and physiological components of the fear response. Central amygdala (CeA) projections to hypothalamic and brain stem nuclei regulate the behavioral and physiological expression of fear, but it is unknown whether these different aspects of the fear response can be separately regulated by the CeA. We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular… Expand
Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response
TLDR
In vivo, local blue-light-induced endogenous OT release robustly decreased freezing responses in fear-conditioned rats and demonstrates that OT release from local axonal endings can specifically control region-associated behaviors. Expand
Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents.
TLDR
It is demonstrated that a morphologically distinct subpopulation of astrocytes expresses OT receptors and mediates anxiolytic and positive reinforcement effects of OT in the central amygdala of mice and rats. Expand
Neuropeptide signalling in the central nucleus of the amygdala
TLDR
It is proposed that neuropeptide signalling in the central amygdala mainly serves to establish or maintain emotional homeostasis in response to threatening and other sensory stimuli. Expand
Amygdala Microcircuits Controlling Learned Fear
TLDR
Key areas of uncertainty remain, particularly with respect to the connectivity of the different cell types, and much evidence indicates that human anxiety disorders results from an abnormal regulation of the networks supporting fear learning. Expand
Synapse-specific astrocyte gating of amygdala-related behavior
TLDR
It is shown that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits, which indicates that animal behavior results from the coordinated activity of neurons and astroCytes. Expand
A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System
TLDR
The results provide first evidence that hypothalamic OT neurons represent a fear memory engram, and identify and permanently tagged a small subpopulation of OT cells, which, by optogenetic stimulation, strongly attenuated contextual fear-induced freezing, and pharmacogenetic silencing of tagged OT neurons impaired context-specific fear extinction. Expand
Oxytocin Promotes Accurate Fear Discrimination and Adaptive Defensive Behaviors
TLDR
The social salience hypothesis is extended by proposing that OT enhances the salience of relevant environmental cues also in non-social contexts, and as such promotes active defensive behaviors. Expand
A competitive inhibitory circuit for selection of active and passive fear responses
TLDR
The balance between conditioned flight and freezing behaviour is regulated by means of local inhibitory connections between CRF+ and SOM+ neurons, indicating that the selection of appropriate behavioural responses to threat is based on competitive interactions between two defined populations of inhibitory neurons, a circuit motif allowing for rapid and flexible action selection. Expand
Inhibitory networks of the amygdala for emotional memory
TLDR
The circuits in amygdala could be drawn more elaborately, and it led to understand how fear or extinction memories are formed in the detailed circuit level, and various neuromodulators affect these circuit activities, inducing subtle behavioral changes. Expand
Wiring Specificity and Synaptic Diversity in the Mouse Lateral Central Amygdala
TLDR
It is reported that the presynaptic cell class determines functional properties of autapses and cannabinoid-mediated modulation of synaptic transmission between neurons, whereas presynptic versus postsynaptic cell classes dictate the connectivity, efficacy, and dynamics of GABAergic synapses between any two neurons. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 59 REFERENCES
Encoding of conditioned fear in central amygdala inhibitory circuits
TLDR
Functional circuit analysis revealed that inhibitory CEA microcircuits are highly organized and that cell-type-specific plasticity of phasic and tonic activity in the CEl to CEm pathway may gate fear expression and regulate fear generalization. Expand
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
TLDR
This work identified two neuronal populations in the central amygdala as part of an inhibitory network, through which vasopressin and oxytocin modulate the integration of excitatory information from the basolateral amygdala and cerebral cortex in opposite manners. Expand
The Central Nucleus of the Amygdala and Corticotropin-Releasing Factor: Insights into Contextual Fear Memory
TLDR
CeA involvement in the consolidation of contextual fear memory and specifically implicate CeA CRF as an important mediator are suggested. Expand
Genetic dissection of an amygdala microcircuit that gates conditioned fear
TLDR
Molecular genetic approaches are used to map the functional connectivity of a subpopulation of GABA-containing neurons, located in the lateral subdivision of the central amygdala (CEl), which express protein kinase C-δ (PKC- δ) and define an inhibitory microcircuit in CEl that gates CEm output to control the level of conditioned freezing. Expand
Characterization of neurons in the rat central nucleus of the amygdala: Cellular physiology, morphology, and opioid sensitivity
TLDR
Models of striatopallidal organization that have identified striatal‐like and pallidal‐like CeA regions are supported that can directly inhibit output from each subdivision by activating postsynaptic MOPRs or KOPRs on distinct subpopulations of opioid‐sensitive neurons. Expand
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
TLDR
It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism. Expand
Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear
TLDR
Electrolytic and ibotenic acid lesions of the LH demonstrate that neurons in the LH are involved in the autonomic, but not the behavioral, conditioned response pathway, whereas neurons inThe caudal CG are involvedIn the behavioral and autonomic pathway, although different efferent projections of the central amygdala thus appear to mediate the behavioraland autonomic concomitants of conditioned fear. Expand
The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory
TLDR
An extended involvement of CeA CRF in contextual memory consolidation is demonstrated and it is demonstrated that contextual fear memory storage is not dependent on a functional CeA. Expand
The role of gastrin-releasing peptide on conditioned fear: differential cortical and amygdaloid responses in the rat
TLDR
These results illustrate that the GRP system can significantly affect the expression of learned fear, and some of the relevant brain sites mediating these effects include the PrL, IL and the CeA, and such effects may be dependent upon whether responses were evoked by environmental contextual fear cues or by specific auditory cues that were explicitly paired with an aversive stimulus. Expand
Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats.
TLDR
There is significant overlap within the amygdala in the neural pathways mediating fear conditioning to contextual and acoustic CS, and that these forms of learning are not anatomically dissociable at the level of amygdaloid nuclei. Expand
...
1
2
3
4
5
...