Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3.

@article{Jurek2015OxytocinRS,
  title={Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3.},
  author={Benjamin Jurek and David A Slattery and Yuichi Hiraoka and Ying Liu and Katsuhiko Nishimori and G. Romero Aguilera and Inga D. Neumann and Erwin H. van den Burg},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 35},
  pages={12248-60}
}
UNLABELLED The major regulator of the neuroendocrine stress response in the brain is corticotropin releasing factor (CRF), whose transcription is controlled by CREB and its cofactors CRTC2/3 (TORC2/3). Phosphorylated CRTCs are sequestered in the cytoplasm, but rapidly dephosphorylated and translocated into the nucleus following a stressful stimulus. As the stress response is attenuated by oxytocin (OT), we tested whether OT interferes with CRTC translocation and, thereby, Crf expression. OT (1… CONTINUE READING
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