Oxytocin Reduces Cocaine Seeking and Reverses Chronic Cocaine-Induced Changes in Glutamate Receptor Function

@article{Zhou2014OxytocinRC,
  title={Oxytocin Reduces Cocaine Seeking and Reverses Chronic Cocaine-Induced Changes in Glutamate Receptor Function},
  author={Luyi Zhou and Wei-Lun Sun and Amy B. Young and Kunhee Lee and Jacqueline F McGinty and Ronald E. See},
  journal={International Journal of Neuropsychopharmacology},
  year={2014},
  volume={18}
}
  • Luyi Zhou, Wei-Lun Sun, R. See
  • Published 22 December 2014
  • Biology, Medicine, Psychology
  • International Journal of Neuropsychopharmacology
Background: Oxytocin, a neurohypophyseal neuropeptide, is a potential mediator and regulator of drug addiction. However, the cellular mechanisms of oxytocin in drug seeking remain unknown. Methods: In the present study, we used a self-administration/reinstatement model to study the effects of oxytocin on cocaine seeking and its potential interaction with glutamate function at the receptor level. Results: Systemic oxytocin dose-dependently reduced cocaine self-administration during various… 

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