Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm: Peripheral vs Central Administration

@article{Ayers2010OxytocinRB,
  title={Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm: Peripheral vs Central Administration},
  author={Luke W Ayers and Galen Missig and Jay Schulkin and Jeffrey B Rosen},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={36},
  pages={2488-2497}
}
Oxytocin is known to have anti-anxiety and anti-stress effects. Using a fear-potentiated startle paradigm in rats, we previously demonstrated that subcutaneously administered oxytocin suppressed acoustic startle following fear conditioning compared with startle before fear conditioning (termed background anxiety), but did not have an effect on cue-specific fear-potentiated startle. The findings suggest oxytocin reduces background anxiety, an anxious state not directly related to cue-specific… CONTINUE READING
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