Oxytocin: a therapeutic target for mental disorders

@article{Matsuzaki2012OxytocinAT,
  title={Oxytocin: a therapeutic target for mental disorders},
  author={Mitsuhiro Matsuzaki and Hiroaki Matsushita and Kazuhito Tomizawa and Hideki Matsui},
  journal={The Journal of Physiological Sciences},
  year={2012},
  volume={62},
  pages={441-444}
}
We review here that oxytocin (OT) is released into blood and within distinct brain regions in response to stressful and social stimuli, and has been shown to have an antidepressant-like effect in animal studies. Clinical reports suggest OT to be a promising drug for psychiatric diseases such as depression, anxiety disorders, schizophrenia, and autism. OT may also have therapeutic potential in the treatment of major depressive disorders, even though OT administered into blood does not readily… Expand
Oxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches
TLDR
How neural and endocrine mechanisms interplay in stress regulation, with an emphasis on the role of OT, is discussed, as well as its therapeutic potential in the treatment of stress-related disorders. Expand
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The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials
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  • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2019
TLDR
Evidence regarding the potential utility of intranasal OT in treating anxiety and depression is still inconclusive and further RCTs with larger samples and long-term administration of IN-OT are needed to better elucidate its potential efficacy alone or in association with standard care. Expand
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TLDR
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TLDR
Evidence is presented that the OXT/AVP systems are involved in the formation of social, working, spatial and episodic memory, mediated by such brain structures as the hippocampal CA2 and CA3 regions, amygdala and prefrontal cortex. Expand
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In the field of neuroscience applied to emotions and affects, some hormones have been studied for their relational and social activation capacity. Among these, the peptide hormone called oxytocin,Expand
Relationship between Oxytocin Level and Major Depressive Disorder
TLDR
Reduced serum oxytocin levels in depressed female patients with cutoff point ≤25.6 denoting that below this level shows probability for major depressive disorder in females, consistent with the hypothesis of dysregulated OXT biology may serve as a biomarker for major depression. Expand
Effect of oxytocin on the behavioral activity in the behavioral despair depression rat model
TLDR
OXT levels were increased in several areas of the brain and in the periphery following the behavioral despair, one stressor, yet pre-treatment with OXT appeared to be beneficial in term of reducing immobility time, suggesting that behavioral despair could enhance OXT synthesis and secretion not only in the brain but also in the peripheral. Expand
The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder
Abstract Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs isExpand
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