Oxytocin: a therapeutic target for mental disorders

  title={Oxytocin: a therapeutic target for mental disorders},
  author={Mitsuhiro Matsuzaki and H. Matsushita and K. Tomizawa and Hideki Matsui},
  journal={The Journal of Physiological Sciences},
  • Mitsuhiro Matsuzaki, H. Matsushita, +1 author Hideki Matsui
  • Published 2012
  • Medicine
  • The Journal of Physiological Sciences
  • We review here that oxytocin (OT) is released into blood and within distinct brain regions in response to stressful and social stimuli, and has been shown to have an antidepressant-like effect in animal studies. Clinical reports suggest OT to be a promising drug for psychiatric diseases such as depression, anxiety disorders, schizophrenia, and autism. OT may also have therapeutic potential in the treatment of major depressive disorders, even though OT administered into blood does not readily… CONTINUE READING
    41 Citations
    Making room for oxytocin in understanding depression
    • 91
    The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials
    • 14
    • PDF
    Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin
    • 2
    • PDF
    Effect of oxytocin on the behavioral activity in the behavioral despair depression rat model
    • 22


    Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders
    • 234
    • PDF
    Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
    • 121
    RGS2 mediates the anxiolytic effect of oxytocin
    • 21
    • PDF
    Brain Oxytocin: A Key Regulator of Emotional and Social Behaviours in Both Females and Males
    • I. Neumann
    • Psychology, Medicine
    • Journal of neuroendocrinology
    • 2008
    • 606
    • PDF
    Plasma oxytocin levels and anxiety in patients with major depression
    • 165
    • PDF
    REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
    • 203
    • PDF
    A Neurotrophic Model for Stress-Related Mood Disorders
    • 2,619
    Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment
    • 121
    • Highly Influential